diff --git a/gnu/packages/bioinformatics.scm b/gnu/packages/bioinformatics.scm
index f8792ef4d4..9f2fd86de2 100644
--- a/gnu/packages/bioinformatics.scm
+++ b/gnu/packages/bioinformatics.scm
@@ -7923,6 +7923,31 @@ (define-public r-biobase
 on Bioconductor or which replace R functions.")
     (license license:artistic2.0)))
 
+(define-public r-bisquerna
+  (package
+   (name "r-bisquerna")
+   (version "1.0.4")
+   (source (origin
+            (method url-fetch)
+            (uri (cran-uri "BisqueRNA" version))
+            (sha256
+             (base32
+              "01g34n87ml7n3pck77497ddgbv3rr5p4153ac8ninpgjijlm3jw2"))))
+   (properties `((upstream-name . "BisqueRNA")))
+   (build-system r-build-system)
+   (propagated-inputs
+    `(("r-biobase" ,r-biobase)
+      ("r-limsolve" ,r-limsolve)))
+   (home-page "https://www.biorxiv.org/content/10.1101/669911v1")
+   (synopsis "Decomposition of Bulk Expression with Single-Cell Sequencing")
+   (description "This package provides tools to accurately estimate cell type
+abundances from heterogeneous bulk expression.  A reference-based method
+utilizes single-cell information to generate a signature matrix and
+transformation of bulk expression for accurate regression based estimates.
+A marker-based method utilizes known cell-specific marker genes to measure
+relative abundances across samples.")
+   (license license:gpl3)))
+
 (define-public r-annotationdbi
   (package
     (name "r-annotationdbi")