diff --git a/gnu/packages/bioconductor.scm b/gnu/packages/bioconductor.scm
index fcd257d672..f1fe9f5c7e 100644
--- a/gnu/packages/bioconductor.scm
+++ b/gnu/packages/bioconductor.scm
@@ -10751,14 +10751,14 @@ (define-public r-a4classif
 (define-public r-a4preproc
   (package
     (name "r-a4preproc")
-    (version "1.44.0")
+    (version "1.46.0")
     (source
      (origin
        (method url-fetch)
        (uri (bioconductor-uri "a4Preproc" version))
        (sha256
         (base32
-         "098yzy7x5536bj76iavismdsdn7x6x07aw0j3knj6i9www9y8yz9"))))
+         "00xs1vayl8v6in79iv7lwbn52yyyq4lv6k3k727g7il8x17mi8i0"))))
     (properties `((upstream-name . "a4Preproc")))
     (build-system r-build-system)
     (propagated-inputs