diff --git a/gnu/local.mk b/gnu/local.mk
index 2a80f36ab7..23893034d5 100644
--- a/gnu/local.mk
+++ b/gnu/local.mk
@@ -1161,7 +1161,6 @@ dist_patch_DATA =						\
   %D%/packages/patches/gnome-shell-disable-test.patch		\
   %D%/packages/patches/gnome-shell-CVE-2020-17489.patch		\
   %D%/packages/patches/gnome-settings-daemon-gc.patch		\
-  %D%/packages/patches/gnome-todo-delete-esource-duplicate.patch \
   %D%/packages/patches/gnome-tweaks-search-paths.patch		\
   %D%/packages/patches/gnupg-default-pinentry.patch		\
   %D%/packages/patches/gnupg-1-build-with-gcc10.patch		\
diff --git a/gnu/packages/gnome.scm b/gnu/packages/gnome.scm
index 800ac415de..70fade1cbe 100644
--- a/gnu/packages/gnome.scm
+++ b/gnu/packages/gnome.scm
@@ -9647,46 +9647,43 @@ (define-public gnome-calendar
 (define-public gnome-todo
   (package
     (name "gnome-todo")
-    (version "3.28.1")
+    (version "40.1")
     (source (origin
               (method url-fetch)
               (uri (string-append "mirror://gnome/sources/" name "/"
-                                  (version-major+minor version) "/"
+                                  (version-major version) "/"
                                   name "-" version ".tar.xz"))
               (sha256
                (base32
-                "08ygqbib72jlf9y0a16k54zz51sncpq2wa18wp81v46q8301ymy7"))
-              (patches
-               (search-patches "gnome-todo-delete-esource-duplicate.patch"))))
+                "1r1fb3zgjvkhx93by24j8cg1w1g3zvwr49vqkscjn261vqs44jq3"))))
     (build-system meson-build-system)
     (arguments
-     '(#:glib-or-gtk? #t
-       #:phases (modify-phases %standard-phases
-                  (add-after
-                      'install 'wrap-gnome-todo
-                    (lambda* (#:key inputs outputs #:allow-other-keys)
-                      (let ((out               (assoc-ref outputs "out"))
-                            (gi-typelib-path   (getenv "GI_TYPELIB_PATH"))
-                            (python-path       (getenv "GUIX_PYTHONPATH")))
-                        (wrap-program (string-append out "/bin/gnome-todo")
-                          ;; XXX: gi plugins are broken.
-                          ;; See https://bugzilla.gnome.org/show_bug.cgi?id=787212
-                          ;; For plugins.
-                          `("GI_TYPELIB_PATH" ":" prefix (,gi-typelib-path))
-                          `("GUIX_PYTHONPATH" ":" prefix (,python-path))))
-                      #t)))))
+     `(#:glib-or-gtk? #t
+       ;; XXX: Some tests fail with the following error:
+       ;; Settings schema 'org.gnome.todo' is not installed.
+       #:tests? #f
+       #:phases
+       (modify-phases %standard-phases
+         (add-after 'unpack 'skip-gtk-update-icon-cache
+           ;; Don't create 'icon-theme.cache'.
+           (lambda _
+             (substitute* "build-aux/meson/meson_post_install.py"
+               (("gtk-update-icon-cache") "true")))))))
     (native-inputs
      `(("gettext" ,gettext-minimal)
        ("gobject-introspection" ,gobject-introspection)
        ("glib:bin" ,glib "bin")         ; For glib-compile-resources
-       ("gtk+-bin" ,gtk+ "bin")         ; For gtk-update-icon-cache
+       ("gtk-bin" ,gtk "bin")           ; For gtk-update-icon-cache
        ("pkg-config" ,pkg-config)))
     (inputs
      `(("rest" ,rest)                   ; For Todoist plugin
+       ("gtk" ,gtk)
        ("json-glib" ,json-glib)         ; For Todoist plugin
+       ("libadwaita" ,libadwaita)
        ("libedataserverui" ,evolution-data-server)
        ("libical" ,libical)
        ("libpeas" ,libpeas)
+       ("libportal" ,libportal)
        ("python-pygobject" ,python-pygobject)
        ("evolution-data-server" ,evolution-data-server)
        ("gnome-online-accounts:lib" ,gnome-online-accounts "lib")
diff --git a/gnu/packages/patches/gnome-todo-delete-esource-duplicate.patch b/gnu/packages/patches/gnome-todo-delete-esource-duplicate.patch
deleted file mode 100644
index c680e86495..0000000000
--- a/gnu/packages/patches/gnome-todo-delete-esource-duplicate.patch
+++ /dev/null
@@ -1,10 +0,0 @@
-From: Emmanuele Bassi <ebassi@gnome.org>
-
-See also: https://gitlab.gnome.org/GNOME/gnome-todo/commit/6cdabc4dd0c6c804a093b94c269461ce376fed4f
---- gnome-todo-3.28.1/plugins/eds/gtd-eds-autoptr.h.orig	2020-05-06 14:20:49.589902539 +0200
-+++ gnome-todo-3.28.1/plugins/eds/gtd-eds-autoptr.h	2020-05-06 14:20:54.593919721 +0200
-@@ -25,4 +25,3 @@
- G_DEFINE_AUTOPTR_CLEANUP_FUNC (ECalComponent, g_object_unref);
- G_DEFINE_AUTOPTR_CLEANUP_FUNC (ECalComponentId, e_cal_component_free_id);
- G_DEFINE_AUTOPTR_CLEANUP_FUNC (ECalClient, g_object_unref);
--G_DEFINE_AUTOPTR_CLEANUP_FUNC (ESource, g_object_unref);