diff --git a/gnu/packages/bioconductor.scm b/gnu/packages/bioconductor.scm
index 79f601d02c..0110db4a81 100644
--- a/gnu/packages/bioconductor.scm
+++ b/gnu/packages/bioconductor.scm
@@ -13769,14 +13769,14 @@ (define-public r-bigmelon
 (define-public r-seqbias
   (package
     (name "r-seqbias")
-    (version "1.44.0")
+    (version "1.46.0")
     (source
      (origin
        (method url-fetch)
        (uri (bioconductor-uri "seqbias" version))
        (sha256
         (base32
-         "085nq6pf0bdn17wsbr5jnyy512v7rf67xff9rp5wz47mcifbv6rg"))))
+         "0mc6lv7vkch138n46gk1q1hfhv37mfxjij39q36wa0jy7s8cagfa"))))
     (properties `((upstream-name . "seqbias")))
     (build-system r-build-system)
     (propagated-inputs