diff --git a/gnu/packages/python-xyz.scm b/gnu/packages/python-xyz.scm
index 9d115790e1..5a4220541e 100644
--- a/gnu/packages/python-xyz.scm
+++ b/gnu/packages/python-xyz.scm
@@ -39,7 +39,7 @@
 ;;; Copyright © 2017 Ben Sturmfels <ben@sturm.com.au>
 ;;; Copyright © 2017, 2018, 2019 Mathieu Othacehe <m.othacehe@gmail.com>
 ;;; Copyright © 2017 José Miguel Sánchez García <jmi2k@openmailbox.org>
-;;; Copyright © 2017, 2020 Roel Janssen <roel@gnu.org>
+;;; Copyright © 2017, 2020, 2021 Roel Janssen <roel@gnu.org>
 ;;; Copyright © 2017, 2018, 2019 Kei Kebreau <kkebreau@posteo.net>
 ;;; Copyright © 2017 Rutger Helling <rhelling@mykolab.com>
 ;;; Copyright © 2017 Muriithi Frederick Muriuki <fredmanglis@gmail.com>
@@ -2020,6 +2020,28 @@ (define-public python-scour
 lossless but can be tweaked for more aggressive cleaning.")
     (license license:asl2.0)))
 
+(define-public python-mappy
+  (package
+   (name "python-mappy")
+   (version "2.18")
+   (source (origin
+            (method url-fetch)
+            (uri (pypi-uri "mappy" version))
+            (sha256
+             (base32
+              "1a05p7rkmxa6qhm108na8flzj2v45jab06drk59kzk1ip2sgvzqq"))))
+   (build-system python-build-system)
+   (native-inputs
+    `(("python-cython" ,python-cython)))
+   (inputs
+    `(("zlib" ,zlib)))
+   (home-page "https://github.com/lh3/minimap2")
+   (synopsis "Python binding for minimap2")
+   (description "This package provides a convenient interface to minimap2,
+a fast and accurate C program to align genomic and transcribe nucleotide
+sequences.")
+   (license license:expat)))
+
 (define-public python-mechanize
   (package
     (name "python-mechanize")