diff --git a/gnu/packages/aux-files/emacs/guix-emacs.el b/gnu/packages/aux-files/emacs/guix-emacs.el
index 9a49e8861c..46ee557f20 100644
--- a/gnu/packages/aux-files/emacs/guix-emacs.el
+++ b/gnu/packages/aux-files/emacs/guix-emacs.el
@@ -2,6 +2,7 @@
 
 ;; Copyright © 2014, 2015, 2016, 2017 Alex Kost <alezost@gmail.com>
 ;; Copyright © 2017 Kyle Meyer <kyle@kyleam.com>
+;; Copyright © 2019 Maxim Cournoyer <maxim.cournoyer@gmail.com>
 
 ;; This file is part of GNU Guix.
 
@@ -24,91 +25,40 @@
 ;; installed with Guix.
 
 ;;; Code:
-
-(require 'cl-lib)
-
-(defvar guix-user-profile (expand-file-name "~/.guix-profile"))
-
-(defvar guix-emacs-autoloads nil
-  "List of the last loaded Emacs autoloads.")
+(require 'seq)
 
 (defvar guix-emacs-autoloads-regexp
-  (rx (group (* any) "-autoloads")
-      ".el" (zero-or-one "c") string-end)
+  (rx (* any) "-autoloads.el" (zero-or-one "c") string-end)
   "Regexp to match Emacs 'autoloads' file.")
 
-(defun guix-emacs-directory (&optional profile)
-  "Return directory with Emacs packages installed in PROFILE.
-If PROFILE is nil, use `guix-user-profile'."
-  (expand-file-name "share/emacs/site-lisp"
-                    (or profile guix-user-profile)))
-
 (defun guix-emacs-find-autoloads (directory)
   "Return a list of Emacs 'autoloads' files in DIRECTORY.
 The files in the list do not have extensions (.el, .elc)."
-  (cl-remove-duplicates
-   (delq nil
-        (mapcar (lambda (file)
-                  (when (string-match guix-emacs-autoloads-regexp file)
-                    (match-string 1 file)))
-                (directory-files directory 'full-name nil 'no-sort)))
-   :test #'string=))
-
-(defun guix-emacs-subdirs (directory)
-  "Return list of DIRECTORY subdirectories."
-  (cl-remove-if (lambda (file)
-                  (or (string-match-p (rx "/." string-end) file)
-                      (string-match-p (rx "/.." string-end) file)
-                      (not (file-directory-p file))))
-                (directory-files directory 'full-name nil 'no-sort)))
-
-(defun guix-emacs-directories (&optional profile)
-  "Return the list of directories under PROFILE that contain Emacs packages.
-This includes both `share/emacs/site-lisp/guix.d/PACKAGE'
-sub-directories and `share/emacs/site-lisp' itself.
-
-If PROFILE is nil, use `guix-user-profile'.
-Return nil, if Emacs packages are not installed in PROFILE."
-  (let ((root-dir (guix-emacs-directory (or profile guix-user-profile))))
-    (when (file-directory-p root-dir)
-      (let* ((pkgs-dir  (expand-file-name "guix.d" root-dir))
-             (pkgs-dirs (when (file-directory-p pkgs-dir)
-                          (guix-emacs-subdirs pkgs-dir))))
-        (cons root-dir pkgs-dirs)))))
+  ;; `directory-files' doesn't honor group in regexp.
+  (mapcar #'file-name-sans-extension
+          (directory-files directory 'full-name guix-emacs-autoloads-regexp)))
 
 ;;;###autoload
-(defun guix-emacs-autoload-packages (&rest profiles)
-  "Autoload Emacs packages installed in PROFILES.
-If PROFILES are not specified, use a default user and system
-profiles.
+(defun guix-emacs-autoload-packages ()
+  "Autoload Emacs packages found in EMACSLOADPATH.
 
-'Autoload' means add directories with Emacs packages to
-`load-path' and load 'autoloads' files matching
+'Autoload' means to load the 'autoloads' files matching
 `guix-emacs-autoloads-regexp'."
-  (interactive (list (if (fboundp 'guix-read-package-profile)
-                         (funcall 'guix-read-package-profile)
-                       guix-user-profile)))
-  (let* ((env      (getenv "GUIX_ENVIRONMENT"))
-         (profiles (or profiles
-                       (append (list "/run/current-system/profile"
-                                     guix-user-profile)
-                               (and env (list env))))))
-    (dolist (profile profiles)
-      (let ((dirs (guix-emacs-directories profile)))
-        (when dirs
-          (let* ((autoloads     (cl-mapcan #'guix-emacs-find-autoloads
-                                           dirs))
-                 (new-autoloads (cl-nset-difference autoloads
-                                                    guix-emacs-autoloads
-                                                    :test #'string=)))
-            (dolist (dir dirs)
-              (cl-pushnew (directory-file-name dir)
-                          load-path
-                          :test #'string=))
-            (dolist (file new-autoloads)
-              (load file 'noerror))
-            (setq guix-emacs-autoloads
-                  (append new-autoloads guix-emacs-autoloads))))))))
+  ;; FIXME: The autoloads generated by the emacs-build-system are not byte
+  ;; compiled.
+  (interactive)
+  (let* ((emacs-load-path (getenv "EMACSLOADPATH"))
+         (emacs-non-core-load-path-directories
+          ;; Filter out core Elisp directories, which are already autoloaded
+          ;; by Emacs.
+          (seq-filter (lambda (dir)
+                        (string-match-p "/share/emacs/site-lisp" dir))
+                      (split-string emacs-load-path ":")))
+          (autoloads (mapcan #'guix-emacs-find-autoloads
+                             emacs-non-core-load-path-directories)))
+    (mapc (lambda (f)
+            (load f 'noerror))
+          autoloads)))
 
 (provide 'guix-emacs)