diff --git a/gnu/packages/bioinformatics.scm b/gnu/packages/bioinformatics.scm
index 4cd90b9e81..c178390eda 100644
--- a/gnu/packages/bioinformatics.scm
+++ b/gnu/packages/bioinformatics.scm
@@ -2384,6 +2384,9 @@ (define-public khmer
 metagenomes and single cells.  Khmer can make de novo assemblies faster, and
 sometimes better.  Khmer can also identify and fix problems with shotgun
 data.")
+    ;; When building on i686, armhf and mips64el, we get the following error:
+    ;; error: ['khmer', 'khmer.tests', 'oxli'] require 64-bit operating system
+    (supported-systems '("x86_64-linux"))
     (license license:bsd-3)))
 
 (define-public macs