diff --git a/gnu/system.scm b/gnu/system.scm
index 39f8465bcb..e813bfc20c 100644
--- a/gnu/system.scm
+++ b/gnu/system.scm
@@ -514,10 +514,16 @@ (define %base-packages
 
          bash-completion
 
+         ;; XXX: We don't use (canonical-package guile-2.2) here because that
+         ;; would create a collision in the global profile between the GMP
+         ;; variant propagated by 'guile-final' and the GMP variant propagated
+         ;; by 'gnutls', itself propagated by 'guix'.
+         guile-2.2
+
          ;; The packages below are also in %FINAL-INPUTS, so take them from
          ;; there to avoid duplication.
          (map canonical-package
-              (list guile-2.2 bash coreutils findutils grep sed
+              (list bash coreutils findutils grep sed
                     diffutils patch gawk tar gzip bzip2 xz lzip))))
 
 (define %default-issue