diff --git a/gnu/packages/bioinformatics.scm b/gnu/packages/bioinformatics.scm
index 90092ddf70..8f0cd0ae77 100644
--- a/gnu/packages/bioinformatics.scm
+++ b/gnu/packages/bioinformatics.scm
@@ -1413,7 +1413,7 @@ (define-public python2-bx-python
 (define-public python-pysam
   (package
     (name "python-pysam")
-    (version "0.9.1.4")
+    (version "0.10.0")
     (source (origin
               (method url-fetch)
               ;; Test data is missing on PyPi.
@@ -1423,7 +1423,7 @@ (define-public python-pysam
               (file-name (string-append name "-" version ".tar.gz"))
               (sha256
                (base32
-                "0y41ssbg6nvn2jgcbnrvkzblpjcwszaiv1rgyd8dwzjkrbfsgsmc"))
+                "1mmvn91agr238kwz7226xq0i7k84lg2nxywn9712mzj7gvgqhfy8"))
               (modules '((guix build utils)))
               (snippet
                ;; Drop bundled htslib. TODO: Also remove samtools and bcftools.