diff --git a/gnu/packages/bioinformatics.scm b/gnu/packages/bioinformatics.scm
index 881c33798d..413f6dfdff 100644
--- a/gnu/packages/bioinformatics.scm
+++ b/gnu/packages/bioinformatics.scm
@@ -885,14 +885,14 @@ (define-public python-cellbender
 (define-public python-htsget
   (package
    (name "python-htsget")
-   (version "0.2.5")
+   (version "0.2.6")
    (source (origin
             (method url-fetch)
             (uri (pypi-uri "htsget" version))
             (sha256
              (base32
-              "0ic07q85vhw9djf23k57b21my7i5xp400m8gfqgr5gcryqvdr0yk"))))
-   (build-system python-build-system)
+              "111q4pzkav26aa3hkgh948wqlyrq7dq6sjml9z63n3blw8s6b0c4"))))
+   (build-system pyproject-build-system)
    (native-inputs
     (list python-setuptools-scm))
    (propagated-inputs