diff --git a/gnu/local.mk b/gnu/local.mk
index 0ed4dd607f..33e108c752 100644
--- a/gnu/local.mk
+++ b/gnu/local.mk
@@ -1846,6 +1846,7 @@ dist_patch_DATA =						\
   %D%/packages/patches/transcode-ffmpeg.patch	\
   %D%/packages/patches/transmission-honor-localedir.patch	\
   %D%/packages/patches/trytond-add-egg-modules-to-path.patch	\
+  %D%/packages/patches/trytond-add-guix_trytond_path.patch	\
   %D%/packages/patches/ttf2eot-cstddef.patch			\
   %D%/packages/patches/tup-unbundle-dependencies.patch		\
   %D%/packages/patches/tuxpaint-stamps-path.patch		\
diff --git a/gnu/packages/patches/trytond-add-guix_trytond_path.patch b/gnu/packages/patches/trytond-add-guix_trytond_path.patch
new file mode 100644
index 0000000000..7dc136ec46
--- /dev/null
+++ b/gnu/packages/patches/trytond-add-guix_trytond_path.patch
@@ -0,0 +1,26 @@
+Make trytond add all paths listed in GUIX_TRYTOND_MODULES_PATH to sys.path.
+
+*** a/trytond/modules/__init__.py	1970-01-01 01:00:01.000000000 +0100
+--- b/trytond/modules/__init__.py	2021-12-02 22:17:28.014612267 +0100
+***************
+*** 31,36 ****
+--- 31,48 ----
+  
+  EGG_MODULES = {}
+  
++ def __extend_python_path__():
++     tryton_python_path = os.environ.get("GUIX_TRYTOND_MODULES_PATH")
++     if tryton_python_path:
++         paths = [path[:-16]  # remove "/trytond/modules"
++                  for path in tryton_python_path.split(os.pathsep)]
++         sys.path.extend(paths)
++         # ensure new paths are in the pkg_resources WorkingSet
++         import pkg_resources
++         list(map(pkg_resources.working_set.add_entry, paths))
++ 
++ __extend_python_path__()
++ 
+  
+  def update_egg_modules():
+      global EGG_MODULES
+l
diff --git a/gnu/packages/tryton.scm b/gnu/packages/tryton.scm
index 0bd5ffcd5b..af8f2f0ab3 100644
--- a/gnu/packages/tryton.scm
+++ b/gnu/packages/tryton.scm
@@ -3,6 +3,7 @@
 ;;; Copyright © 2020 Vinicius Monego <monego@posteo.net>
 ;;; Copyright © 2021 Maxime Devos <maximedevos@telenet.be>
 ;;; Copyright © 2021 Hartmut Goebel <h.goebel@crazy-compilers.com>
+;;; Copyright © 2021 Maxim Cournoyer <maxim.cournoyer@gmail.com>
 ;;;
 ;;; This file is part of GNU Guix.
 ;;;
@@ -39,6 +40,19 @@ (define-module (gnu packages tryton)
   #:use-module (guix utils)
   #:use-module (guix build-system python))
 
+(define (guix-trytonpath-search-path version)
+  "Generate a GUIX_TRYTOND_MODULES_PATH search path specification, using
+VERSION.
+
+Do not use PYTHHONPATH not avoid interfering with any different Python package
+installed in the same environments.  Collecting only paths actually containing
+/tryton/modules reduces the number of paths."
+  (search-path-specification (variable "GUIX_TRYTOND_MODULES_PATH")
+                             (files (list (string-append
+                                           "lib/python"
+                                           (version-major+minor version)
+                                           "/site-packages/trytond/modules")))))
+
 (define-public trytond
   (package
     (name "trytond")
@@ -49,7 +63,8 @@ (define-public trytond
        (uri (pypi-uri "trytond" version))
        (sha256
         (base32 "1jp5cadqpwkcnml8r1hj6aak5kc8an2d5ai62p96x77nn0dp3ny4"))
-       (patches (search-patches "trytond-add-egg-modules-to-path.patch"))))
+       (patches (search-patches "trytond-add-egg-modules-to-path.patch"
+                                "trytond-add-guix_trytond_path.patch"))))
     (build-system python-build-system)
     (propagated-inputs
      (list python-dateutil
@@ -65,6 +80,8 @@ (define-public trytond
            python-wrapt))
     (native-inputs
      (list python-mock python-pillow))
+    (native-search-paths
+     (list (guix-trytonpath-search-path (package-version python))))
     (arguments
      `(#:phases
        (modify-phases %standard-phases