diff --git a/guix/build-system/r.scm b/guix/build-system/r.scm
index 620822b870..9b360ae581 100644
--- a/guix/build-system/r.scm
+++ b/guix/build-system/r.scm
@@ -61,7 +61,7 @@ (define* (bioconductor-uri name version #:optional type)
                          "/src/contrib/"
                          name "_" version ".tar.gz")
           ;; TODO: use %bioconductor-version from (guix import cran)
-          (string-append "https://bioconductor.org/packages/3.15"
+          (string-append "https://bioconductor.org/packages/3.16"
                          type-url-part
                          "/src/contrib/"
                          name "_" version ".tar.gz"))))
diff --git a/guix/import/cran.scm b/guix/import/cran.scm
index 278743d496..286a4c21b9 100644
--- a/guix/import/cran.scm
+++ b/guix/import/cran.scm
@@ -188,9 +188,9 @@ (define %cran-url "https://cran.r-project.org/web/packages/")
 (define %cran-canonical-url "https://cran.r-project.org/package=")
 (define %bioconductor-url "https://bioconductor.org/packages/")
 
-;; The latest Bioconductor release is 3.15.  Bioconductor packages should be
+;; The latest Bioconductor release is 3.16.  Bioconductor packages should be
 ;; updated together.
-(define %bioconductor-version "3.15")
+(define %bioconductor-version "3.16")
 
 (define* (bioconductor-packages-list-url #:optional type)
   (string-append "https://bioconductor.org/packages/"